ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:

Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)

Biological characterization of new molecular entities in the context of drug discovery

Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.

Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry

Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources

Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response

Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic

Mechanistic drug metabolism and regulation of metabolic enzyme gene expression

Chemistry patents relevant to the medicinal chemistry field.

《Acs Medicinal Chemistry Letters》是一本由AMER CHEMICAL SOC出版商出版的专业医学期刊，该刊创刊于2010年，刊期12 issues/year，该刊已被国际权威数据库SCIE收录。在中科院最新升级版分区表中，该刊分区信息为大类学科：医学 3区，小类学科：药物化学 3区；在JCR（Journal Citation Reports）分区等级为Q2。该刊发文范围涵盖药物化学等领域，旨在及时、准确、全面地报道国内外药物化学工作者在该领域取得的最新研究成果、工作进展及学术动态、技术革新等，促进学术交流，鼓励学术创新。2021年影响因子为4.632，平均审稿速度一般,3-8周。