The journal's scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations.

Research areas include:

Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genes

Studies of the expression, structure and function of the products of immune-related genes

Immunogenetics of susceptibility to infectious and autoimmune disease, and allergy

The role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplant

Histocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivity

Studies of immunologic tolerance and pregnancy

T cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal's scope

Pharmacogenomics and vaccine development in the context of immune-related genes

Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered.

Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.

《Human Immunology》是一本由ELSEVIER SCIENCE INC出版商出版的专业医学期刊，该刊创刊于1980年，刊期Monthly，该刊已被国际权威数据库SCIE、SCI收录。在中科院最新升级版分区表中，该刊分区信息为大类学科：医学 4区，小类学科：免疫学 4区；在JCR（Journal Citation Reports）分区等级为Q4。该刊发文范围涵盖免疫学等领域，旨在及时、准确、全面地报道国内外免疫学工作者在该领域取得的最新研究成果、工作进展及学术动态、技术革新等，促进学术交流，鼓励学术创新。2021年影响因子为2.211，平均审稿速度平均1.5月。