Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.

《Biophysical Chemistry》是一本由ELSEVIER出版商出版的专业生物期刊，该刊创刊于1974年，刊期Semimonthly，该刊已被国际权威数据库SCIE、SCI收录。在中科院最新升级版分区表中，该刊分区信息为大类学科：生物学 4区，小类学科：生化与分子生物学 4区；生物物理 4区；物理化学 4区；在JCR（Journal Citation Reports）分区等级为Q2。该刊发文范围涵盖生化与分子生物学等领域，旨在及时、准确、全面地报道国内外生化与分子生物学工作者在该领域取得的最新研究成果、工作进展及学术动态、技术革新等，促进学术交流，鼓励学术创新。2021年影响因子为3.628，平均审稿速度约1.0个月。